Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Total revenues, net	$ 83,138	$ 69,888	$ 24,181
Costs and expenses:
Cost of goods sold	25,333	4,833	641
Selling, general and administrative	137,184	138,402	120,614
Pre-approval commercial manufacturing	2,304	22,767	26,545
Research and development	74,007	91,378	86,123
Total costs and expenses	238,828	257,380	233,923
Loss from operations	(155,690)	(187,492)	(209,742)
Other (expense) income, net	(22,166)	(12,179)	(22,824)
Loss before income taxes	(177,856)	(199,671)	(232,566)
Income tax expense (benefit)	5,245	(90)	3
Net loss	$ (183,101)	$ (199,581)	$ (232,569)
Net loss per common share - basic and diluted (in dollars per share)	$ (3.99)	$ (4.39)	$ (5.58)
Weighted average number of common shares outstanding—basic and diluted (in shares)	45,897,255	45,427,154	41,663,958
Unrealized (loss) gain on available-for-sale investments	$ 40	$ (92)	$ 28
Comprehensive loss	(183,061)	(199,673)	(232,541)
Product revenues, net
Total revenues, net	$ 83,138	$ 69,888	$ 24,181