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Stock-based Compensation (Tables)
 12 Months Ended
Dec. 31, 2020
Share-based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, RSAs, PSAs, RSUs, SARs and stock purchase rights is reflected in the consolidated statements of operations and comprehensive loss as follows:
YEAR ENDED DECEMBER 31,
(in thousands)202020192018
Cost of goods sold$2,353 $— $— 
Selling, general and administrative27,176 30,463 26,432 
Pre-approval commercial manufacturing344 3,634 2,622 
Research and development10,222 10,996 9,674 
Total$40,095 $45,093 $38,728 
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions
Weighted average assumptions utilized in the fair value calculation for options to purchase common stock as of December 31, 2020, 2019 and 2018 are as follows: 
 YEAR ENDED
DECEMBER 31,
 202020192018
Expected term (years)6.06.06.0
Expected stock price volatility74 %74 %78 %
Risk-free interest rate0.9 %1.9 %2.7 %
Dividend yield— %— %— %
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 2019
8,425,551 $29.06 
Granted874,878 16.83 
Exercised(58,676)5.28 
Canceled(653,139)37.18 
Options outstanding at December 31, 2020
8,588,614 $27.36 5.9$15,180 
Options exercisable at December 31, 2020
6,405,232 $26.44 5.0$14,959 
Schedule of Stock Options Outstanding and Exercisable Option Plans
The following table provides additional information about stock options that are outstanding and exercisable at December 31, 2020:
EXERCISE
PRICE		OPTIONS
OUTSTANDING		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		OPTIONS
EXERCISABLE
$0.20 - $10.00
1,407,002 2.51,407,002 
$10.01 - $20.00
1,472,021 6.7962,151 
$20.01 - $30.00
2,763,163 6.11,841,580 
$30.01 - $45.00
1,185,530 6.7929,942 
$45.01 - $55.00
1,061,299 7.2744,904 
$55.01 - $73.10
699,599 7.2519,653 
8,588,614 6,405,232 
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSA, including PSAs, activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Nonvested RSAs at December 31, 2019
754,415 $43.07 
Granted424,613 14.37 
Vested(267,872)42.85 
Canceled(101,629)35.65 
Nonvested RSAs at December 31, 2020
809,527 $29.03 
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Nonvested RSUs at December 31, 2019
41,811 $19.22 
Granted85,305 12.76 
Vested(12,567)19.22 
Canceled(7,367)14.03 
Nonvested RSUs at December 31, 2020
107,182 $14.43 
Schedule of Stock Appreciation Rights
The following table summarizes the SARs activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2019
163,016 $41.70 
Granted73,500 13.95 
Exercised— — 
Canceled(24,472)40.00 
SARs outstanding at December 31, 2020
212,044 $32.28 3.5$46 
SARs exercisable at December 31, 2020
50,133 $45.24 2.8$—