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Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2020
Income Tax Disclosure [Abstract]  
Schedule of Components of Provision for Income Taxes
The provision for income taxes is based on net loss before income taxes as follows:
 DECEMBER 31,
(in thousands)202020192018
Net loss before income taxes:
United States$(143,349)$(153,620)$(203,230)
Non-U.S.(34,507)(46,051)(29,336)
Net loss before income taxes$(177,856)$(199,671)$(232,566)

DECEMBER 31,
(in thousands, except percentages)202020192018
Provision for income taxes:
Current:
United States $(33)$(90)$3 
Non-U.S.5,278 — — 
Total$5,245 $(90)$3 
Deferred:
United States $— $— $— 
Non-U.S.— — — 
Total— — — 
Provision for income taxes$5,245 $(90)$3 
Effective tax rate(2.95)%0.05 %— %
Schedule of Significant Components of Company's Net Deferred Income Tax Assets
Significant components of the Company’s net deferred income tax assets as of December 31, 2020 and 2019 consist of the following:
 DECEMBER 31,
(in thousands)20202019
Net deferred tax assets:
Net operating loss carryforwards$169,070 $142,991 
Stock-based compensation29,884 22,785 
U.S. tax credit carryforwards13,526 10,980 
Envisia asset acquisition5,007 5,476 
Basis difference in intangibles7,625 7,625 
Convertible Notes(19,028)(22,822)
Other assets10,697 8,996 
Other liabilities(5,416)(5,709)
Valuation allowance(211,365)(170,322)
Total net deferred income taxes$— $— 
Schedule of Reconciliation of U.S. Statutory Rate and Effective Tax Rate
A reconciliation of the statutory tax rates and the effective tax rates for the years ended December 31, 2020, 2019 and 2018 is as follows:
 DECEMBER 31,
 202020192018
U.S. federal tax rate21.00 %21.00 %21.00 %
State income taxes, net of federal benefit4.02 %4.97 %4.56 %
Non-taxable foreign loss(4.81)%(4.44)%0.09 %
Stock-based compensation(2.29)%(1.47)%1.97 %
Other0.48 %0.98 %(1.13)%
Change in valuation allowance(21.35)%(20.99)%(26.49)%
Effective tax rate(2.95)%0.05 %— %