Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019
Cash flows from operating activities
Net loss	$ (136,964)	$ (144,517)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation	4,741	3,610
Amortization and accretion	20,446	6,335
Stock-based compensation	30,505	33,921
Other non-cash	(369)	(252)
Changes in operating assets and liabilities
Accounts receivable, net	(8,494)	(30,563)
Inventory	915	(4,080)
Prepaid, current and other assets	(371)	(2,715)
Accounts payable, accrued expenses and other current liabilities	6,884	18,576
Operating lease liabilities	(4,345)	(3,621)
Net cash used in operating activities	(87,052)	(123,306)
Cash flows from investing activities
Purchase of available-for-sale investments	(84,111)	(97,268)
Proceeds from sales and maturities of investments	160,769	0
Purchase of property, plant and equipment	(2,504)	(7,911)
Net cash provided by (used in) investing activities	74,154	(105,179)
Cash flows from financing activities
Proceeds from loan	8,274	0
Repayment of loan	(8,274)	0
Proceeds from convertible notes, net of issuance costs	0	308,349
Payment for capped call options	0	(32,890)
Payments related to issuance of stock for stock-based compensation arrangements, net	(1,255)	(597)
Payments of debt issuance costs	0	(532)
Proceeds from exercise of warrants	0	375
Other financing	0	(336)
Net cash (used in) provided by financing activities	(1,255)	274,369
Net change in cash and cash equivalents	(14,153)	45,884
Cash and cash equivalents, at beginning of period	143,940	202,818
Cash and cash equivalents, at end of period	129,787	248,702
Non-cash investing and financing activities
Purchase of property, plant and equipment	321	1,389
Debt issuance costs included in accrued expense and other current liabilities	$ 0	$ 1,275