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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2020
Share-based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, RSAs, PSAs, RSUs and SARs is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:
 THREE MONTHS ENDED 
SEPTEMBER 30,		NINE MONTHS ENDED 
SEPTEMBER 30,
(in thousands)2020201920202019
Cost of goods sold$511 $— $1,678 $— 
Selling, general and administrative6,716 7,041 20,524 23,253 
Pre-approval commercial manufacturing28 807 344 2,490 
Research and development2,545 2,758 7,959 8,178 
Total$9,800 $10,606 $30,505 $33,921 
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 2019
8,425,551 $29.06 
Granted868,620 16.87 
Exercised(58,676)5.28 
Canceled(445,310)41.59 
Options outstanding at September 30, 2020
8,790,185 $27.38 6.2$12,418 
Options exercisable at September 30, 2020
6,117,232 $25.98 5.1$12,418 
Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSAs, including PSAs, activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2019
754,415 $43.07 
Granted423,206 14.39 
Vested(261,622)43.42 
Canceled(57,852)40.74 
Non-vested RSAs at September 30, 2020
858,147 $28.98 
Share-based Payment Arrangement, Stock Appreciation Right, Activity
The following table summarizes the SARs activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2019
163,016 $41.70 
Granted71,500 14.03 
Canceled(21,094)41.37 
SARs outstanding at September 30, 2020
213,422 $32.46 3.7$1 
SARs exercisable at September 30, 2020
49,857 $45.17 3.0$—