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Stock-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2020
Share-based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, RSAs, PSAs, RSUs and SARs is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:
 THREE MONTHS ENDED 
JUNE 30,		SIX MONTHS ENDED 
JUNE 30,
(in thousands)2020201920202019
Cost of goods sold$670  $—  $1,167  $—  
Selling, general and administrative6,900  7,091  $13,808  $16,212  
Pre-approval commercial manufacturing22  834  316  1,683  
Research and development2,584  2,770  5,414  5,420  
Total$10,176  $10,695  $20,705  $23,315  
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 20198,425,551  $29.06  
Granted556,133  19.20  
Exercised(43,676) 6.59  
Canceled(309,255) 41.62  
Options outstanding at June 30, 20208,628,753  $28.09  6.4$17,178  
Options exercisable at June 30, 20205,945,696  $25.69  5.3$17,066  
Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSAs, including PSAs, activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2019754,415  $43.07  
Granted100,852  19.72  
Vested(231,443) 44.84  
Canceled(44,901) 41.71  
Non-vested RSAs at June 30, 2020578,923  $38.41  
Share-based Payment Arrangement, Stock Appreciation Right, Activity
The following table summarizes the SARs activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2019163,016  $41.70  
Granted23,000  16.89  
Canceled(18,122) 42.87  
SARs outstanding at June 30, 2020167,894  $38.17  3.6$4  
SARs exercisable at June 30, 202038,107  $51.32  3.0$—