Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Total revenues, net	$ 69,888	$ 24,181	$ 0
Costs and expenses:
Cost of goods sold	4,833	641	0
Selling, general and administrative	138,402	120,614	56,905
Pre-approval commercial manufacturing	22,767	26,545	16,710
Research and development	91,378	86,123	72,078
Total costs and expenses	257,380	233,923	145,693
Loss from operations	(187,492)	(209,742)	(145,693)
Other (expense) income, net	(12,179)	(22,824)	(1,170)
Loss before income taxes	(199,671)	(232,566)	(146,863)
Income tax (benefit) expense	(90)	3	(1,758)
Net loss	$ (199,581)	$ (232,569)	$ (145,105)
Net loss per common share - basic and diluted (in dollars per share)	$ (4.39)	$ (5.58)	$ (4.11)
Weighted average number of common shares outstanding—basic and diluted (in shares)	45,427,154	41,663,958	35,324,472
Net loss	$ (199,581)	$ (232,569)	$ (145,105)
Unrealized (loss) gain on available-for-sale investments	(92)	28	40
Comprehensive loss	(199,673)	(232,541)	(145,065)
Product revenues, net
Total revenues, net	$ 69,888	$ 24,181	$ 0