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The Company (Details)		1 Months Ended		3 Months Ended	5 Months Ended	12 Months Ended			29 Months Ended
The Company (Details)	Aug. 01, 2018 USD ($)	Nov. 30, 2019 USD ($)	Oct. 31, 2017 USD ($) shares	Oct. 31, 2017 USD ($)	Dec. 31, 2018 USD ($)	Dec. 31, 2019 USD ($) segment product	Dec. 31, 2018 USD ($)	Dec. 31, 2017 USD ($)	Dec. 31, 2020 USD ($)	Sep. 30, 2019 USD ($)	May 31, 2019 USD ($)	Jul. 31, 2018 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Number of operating segments \| segment						1
Number U.S. FDA approved products \| product						2
Research and development						$ 91,378,000	$ 86,123,000	$ 72,078,000
Delayed Draw Term Loan \| Revolving Credit Facility
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Maximum borrowing capacity										$ 200,000,000	$ 100,000,000	$ 100,000,000
Convertible debt \| Convertible Senior Notes Due 2024
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Principal amount						$ 316,250,000				$ 316,250,000
Debt instrument, interest rate percentage										1.50%
DSM Collaborative Arrangement
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Research and development							$ 9,600,000
Amount paid due to collaboration arrangement	$ 6,000,000.0				$ 3,000,000.0
Contingent payments due (up to)	$ 75,000,000
DSM Collaborative Arrangement \| Scenario, Forecast
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Amount of to be paid due to collaborative agreement									$ 9,000,000.0
Avizorex
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Asset acquisition, consideration transferred		$ 10,200,000
Milestone payments contingent upon the achievement of certain approvals		69,000,000.0
Research and development		$ 10,200,000
Envisia
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Milestone payments contingent upon the achievement of certain approvals			$ 45,000,000.0
Upfront cash payment			$ 10,500,000
Common stock, shares issued (in shares) \| shares			263,146
Common stock value			$ 14,300,000
Research and development				$ 24,800,000