Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Total revenues, net	$ 18,544	$ 7,302	$ 45,231	$ 9,725
Costs and expenses:
Cost of goods sold	2,063	205	3,149	264
Selling, general and administrative	32,171	32,685	102,935	88,727
Pre-approval commercial manufacturing	5,841	7,248	16,117	18,920
Research and development	21,796	28,502	60,584	59,631
Total costs and expenses	61,871	68,640	182,785	167,542
Loss from operations	(43,327)	(61,338)	(137,554)	(157,817)
Other (expense) income, net	(6,075)	(24,050)	(7,053)	(23,291)
Loss before income taxes	(49,402)	(85,388)	(144,607)	(181,108)
Income tax (benefit) expense	0	0	(90)	3
Net loss	$ (49,402)	$ (85,388)	$ (144,517)	$ (181,111)
Net loss per common share—basic and diluted (in dollars per share)	$ (1.09)	$ (1.96)	$ (3.19)	$ (4.47)
Weighted average number of common shares outstanding—basic and diluted (in shares)	45,448,190	43,657,423	45,372,608	40,505,534
Net loss	$ (49,402)	$ (85,388)	$ (144,517)	$ (181,111)
Unrealized (loss) gain on available-for-sale investments	(158)	8	(158)	27
Comprehensive loss	(49,560)	(85,380)	(144,675)	(181,084)
Product revenues, net
Total revenues, net	$ 18,544	$ 7,302	$ 45,231	$ 9,725