Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2019

Share-based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Expense

Stock-based compensation expense for options granted, RSAs, performance stock awards (“PSAs”), RSUs, SARs and stock purchase rights is reflected in the condensed consolidated statements of operations and comprehensive loss as follows: 

	THREE MONTHS ENDED   SEPTEMBER 30,				NINE MONTHS ENDED   SEPTEMBER 30,
(in thousands)	2019		2018		2019		2018
Selling, general and administrative	$	7,041	$	6,682	$	23,253	$	20,022
Pre-approval commercial manufacturing	807		700		2,490		1,804
Research and development	2,758		2,596		8,178		7,189
Total	$	10,606	$	9,978	$	33,921	$	29,015

Schedule of Stock Options Activity

The following table summarizes the stock option activity under the Plans: 

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
Options outstanding at December 31, 2018	6,935,119		$	28.96
Granted	2,046,583		32.54
Exercised	(139,119	)	28.74
Canceled	(307,317	)	51.53
Options outstanding at September 30, 2019	8,535,266		$	29.02	6.8	$	28,534
Options exercisable at September 30, 2019	5,404,516		$	23.00	5.4	$	28,304

Restricted Stock and Restricted Stock Units Activity

The following table summarizes the RSAs, including PSAs, activity under the Plans: 

	NUMBER OF SHARES		WEIGHTED AVERAGE FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2018	572,706		$	48.18
Granted	494,167		41.13
Vested	(214,276	)	45.76
Canceled	(97,418	)	48.85
Non-vested RSAs at September 30, 2019	755,179		$	44.20

Schedule of Stock Appreciation Rights

The following table summarizes the SARs activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
SARs outstanding at December 31, 2018	91,000		$	53.83
Granted	113,851		33.73
Exercised	—		—
Canceled	(26,687	)	50.15
SARs outstanding at September 30, 2019	178,164		$	41.49	4.2	$	—
SARs exercisable at September 30, 2019	17,250		$	54.35	3.5	$	—