Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Total revenues, net	$ 15,835	$ 2,423	$ 26,687	$ 2,423
Costs and expenses:
Cost of goods sold	705	59	1,086	59
Selling, general and administrative	34,482	33,112	70,764	56,042
Pre-approval commercial manufacturing	5,819	6,779	10,276	11,672
Research and development	20,904	18,157	38,788	31,129
Total costs and expenses	61,910	58,107	120,914	98,902
Loss from operations	(46,075)	(55,684)	(94,227)	(96,479)
Other (expense) income, net	(1,089)	663	(978)	759
Loss before income taxes	(47,164)	(55,021)	(95,205)	(95,720)
Income tax expense (benefit)	0	3	(90)	3
Net loss	$ (47,164)	$ (55,024)	$ (95,115)	$ (95,723)
Net loss per common share—basic and diluted (in dollars per share)	$ (1.04)	$ (1.40)	$ (2.10)	$ (2.46)
Weighted average number of common shares outstanding—basic and diluted (in shares)	45,397,024	39,204,762	45,334,191	38,903,469
Net loss	$ (47,164)	$ (55,024)	$ (95,115)	$ (95,723)
Unrealized gain on available-for-sale investments	0	148	0	19
Comprehensive loss	(47,164)	(54,876)	(95,115)	(95,704)
Product revenues, net
Total revenues, net	$ 15,835	$ 2,423	$ 26,687	$ 2,423