Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2019

Share-based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Expense

Stock-based compensation expense for options granted, RSAs, performance stock awards (“PSAs”), SARs and stock purchase rights is reflected in the condensed consolidated statements of operations and comprehensive loss as follows: 

	THREE MONTHS ENDED   JUNE 30,				SIX MONTHS ENDED   JUNE 30,
(in thousands)	2019		2018		2019		2018
Selling, general and administrative	$	7,091	$	7,126	$	16,212	$	13,340
Pre-approval commercial manufacturing	834		634		1,683		1,104
Research and development	2,770		2,558		5,420		4,593
Total	$	10,695	$	10,318	$	23,315	$	19,037

Schedule of Stock Options Activity

The following table summarizes the stock option activity under the Plans: 

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
Options outstanding at December 31, 2018	6,935,119		$	28.97
Granted	914,790		43.32
Exercised	(124,034	)	30.94
Canceled	(211,607	)	53.52
Options outstanding at June 30, 2019	7,514,268		$	29.99	6.6	$	63,671
Options exercisable at June 30, 2019	5,145,383		$	21.98	5.6	$	61,881

Restricted Stock and Restricted Stock Units Activity

The following table summarizes the RSAs, including PSAs, activity under the Plans: 

	NUMBER OF SHARES		WEIGHTED AVERAGE FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2018	572,706		$	48.18
Granted	392,784		45.55
Vested	(203,077	)	45.12
Canceled	(33,708	)	50.55
Non-vested RSAs at June 30, 2019	728,705		$	47.53

Schedule of Stock Appreciation Rights

The following table summarizes the SARs activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
SARs outstanding at December 31, 2018	91,000		$	53.75
Granted	57,851		43.40
Exercised	—		—
Canceled	(19,445	)	50.87
SARs outstanding at June 30, 2019	129,406		$	49.55	4.1	$	—
SARs exercisable at June 30, 2019	18,000		$	54.19	3.7	$	—