Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Total revenues, net	$ 10,852	$ 0
Costs and expenses:
Cost of goods sold	381	0
Selling, general and administrative	36,282	22,930
Pre-approval commercial manufacturing	4,457	4,893
Research and development	17,884	12,972
Total costs and expenses	59,004	40,795
Loss from operations	(48,152)	(40,795)
Other income (expense), net	111	96
Loss before income taxes	(48,041)	(40,699)
Income tax benefit	(90)	0
Net loss	$ (47,951)	$ (40,699)
Net loss per common share—basic and diluted (in dollars per share)	$ (1.06)	$ (1.05)
Weighted average number of common shares outstanding—basic and diluted (in shares)	45,270,660	38,598,827
Net loss	$ (47,951)	$ (40,699)
Unrealized gain (loss) on available-for-sale investments		(129)
Comprehensive loss	(47,951)	(40,828)
Product revenues, net
Total revenues, net	$ 10,852	$ 0