Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Total revenues, net	$ 24,181	$ 0	$ 0
Costs and expenses:
Cost of goods sold	641	0	0
Selling, general and administrative	120,614	56,905	34,706
Pre-approval commercial manufacturing	26,545	16,710	9,772
Research and development	86,123	72,078	52,394
Total costs and expenses	233,923	145,693	96,872
Loss from operations	(209,742)	(145,693)	(96,872)
Other income (expense), net	(22,824)	(1,170)	(1,994)
Loss before income taxes	(232,566)	(146,863)	(98,866)
Income tax expense (benefit)	3	(1,758)	193
Net loss	$ (232,569)	$ (145,105)	$ (99,059)
Net loss per common share - basic and diluted (in dollars per share)	$ (5.58)	$ (4.11)	$ (3.40)
Weighted average number of common shares outstanding—basic and diluted (in shares)	41,663,958	35,324,472	29,135,583
Net loss	$ (232,569)	$ (145,105)	$ (99,059)
Unrealized gain on available-for-sale investments	28	40	111
Comprehensive loss	(232,541)	(145,065)	(98,948)
Product revenues, net
Total revenues, net	$ 24,181	$ 0	$ 0