Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2018

Accounting Policies [Abstract]

Schedule of Estimated Useful Lives

Estimated useful lives by major asset category are as follows:

Manufacturing equipment	10 years
Laboratory equipment	7 years
Furniture and fixtures	5 years
Software, computer and other equipment	3 years
Leasehold improvements	Lower of estimated useful life or term of lease

Property, plant and equipment, net consists of the following:

(in thousands)	DECEMBER 31,
	2018			2017
Manufacturing equipment	$	2,366		$	2,082
Laboratory equipment	6,038			3,602
Furniture and fixtures	1,815			1,209
Software, computer and other equipment	2,702			1,932
Leasehold improvements	4,072			1,887
Construction-in-progress	49,057			24,228
Property, plant and equipment	66,050			34,940
Less: Accumulated depreciation	(5,525		)	(3,008		)
Property, plant and equipment, net	$	60,525		$	31,932

Schedule of Computation of Diluted EPS

The potential common stock equivalents that have been excluded from the computation of Diluted EPS consist of the following:

	DECEMBER 31,
	2018	2017	2016
2014 Convertible Notes	—	5,040,323	5,040,323
Outstanding stock options	6,935,119	6,457,343	5,255,930
Stock purchase warrants	154,500	157,500	157,500
Nonvested restricted stock awards	572,706	447,049	164,194