Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues	$ 7,302	$ 0	$ 9,725	$ 0
Costs and expenses:
Cost of goods sold	205	0	264	0
Selling, general and administrative	39,933	19,774	107,647	51,402
Research and development	28,502	12,408	59,631	33,977
Total costs and expenses	68,640	32,182	167,542	85,379
Loss from operations	(61,338)	(32,182)	(157,817)	(85,379)
Other income (expense), net	(24,050)	(141)	(23,291)	(1,071)
Loss before income taxes	(85,388)	(32,323)	(181,108)	(86,450)
Income tax expense	0	49	3	142
Net loss	$ (85,388)	$ (32,372)	$ (181,111)	$ (86,592)
Net loss per common share—basic and diluted (in dollars per share)	$ (1.96)	$ (0.89)	$ (4.47)	$ (2.48)
Weighted average number of common shares outstanding—basic and diluted (in shares)	43,657,423	36,210,329	40,505,534	34,932,551
Net loss	$ (85,388)	$ (32,372)	$ (181,111)	$ (86,592)
Unrealized gain (loss) on available-for-sale investments	8	(17)	27	(30)
Comprehensive loss	(85,380)	(32,389)	(181,084)	(86,622)
Product revenues, net
Revenues	$ 7,302	$ 0	$ 9,725	$ 0