Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Stock-Based Compensation Expense for Options Granted, Restricted Stock and Stock Purchase Rights as Reflected in Statement of Operations

Stock-based compensation expense for options granted, RSAs, performance stock awards (“PSAs”), SARs and stock purchase rights is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:

	THREE MONTHS ENDED   SEPTEMBER 30,				NINE MONTHS ENDED   SEPTEMBER 30,
(in thousands)	2018		2017		2018		2017
Selling, general and administrative	$	7,382	$	4,995	$	21,826	$	14,032
Research and development	2,596		1,562		7,189		4,040
Total	$	9,978	$	6,557	$	29,015	$	18,072

Schedule of Stock Options Activity

The following table summarizes the stock option activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
Options outstanding at December 31, 2017	6,457,343		$	22.15
Granted	1,207,984		56.81
Exercised	(600,690	)	8.74
Canceled	(112,998	)	46.01
Options outstanding at September 30, 2018	6,951,639		$	28.92	7.0	$	227,793
Options exercisable at September 30, 2018	4,440,403		$	18.39	5.9	$	191,690

Restricted Stock and Restricted Stock Units Activity

The following table summarizes the RSAs, including PSAs, activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE FAIR VALUE PER SHARE
Nonvested RSAs at December 31, 2017	447,049		$	41.08
Granted	264,999		56.00
Vested	(122,461	)	38.47
Canceled	(5,463	)	48.41
Nonvested RSAs at September 30, 2018	584,124		$	48.32