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Stock-Based Compensation - Stock-Based Compensation Expense for Options Granted, Restricted Stock and Stock Purchase Rights as Reflected in Statement of Operations (Detail) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Stock-based compensation expense $ 8,719 $ 4,850
Selling, general and administrative    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Stock-based compensation expense 6,684 3,786
Research and development    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Stock-based compensation expense 2,035 $ 1,064
Restricted stock    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Unrecognized compensation expense, other than options 23,100  
Stock Appreciation Rights (SARs)    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Liability-based awards unrecognized compensation expense $ 1,600  
Liability-based awards unrecognized compensation expense (in years) 3 years 11 months 9 days