Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2018

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Stock-Based Compensation Expense for Options Granted, Restricted Stock and Stock Purchase Rights as Reflected in Statement of Operations

Stock-based compensation expense for options granted, RSAs, performance stock awards (“PSAs”), SARs and stock purchase rights is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:

	THREE MONTHS ENDED   MARCH 31,
(in thousands)	2018		2017
Selling, general and administrative	$	6,684	$	3,786
Research and development	2,035		1,064
Total	$	8,719	$	4,850

Schedule of Stock Options Activity

The following table summarizes the stock option activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
Options outstanding at December 31, 2017	6,457,343		$	22.15
Granted	793,236		55.47
Exercised	(41,857	)	19.61
Canceled	(82,775	)	46.18
Options outstanding at March 31, 2018	7,125,947		$	25.57	7.2	$	207,230
Options exercisable at March 31, 2018	4,427,796		$	14.58	6.1	$	175,649

Restricted Stock and Restricted Stock Units Activity

The following table summarizes the RSAs, including PSAs, activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE FAIR VALUE PER SHARE
Nonvested RSAs at December 31, 2017	447,049		$	41.08
Granted	242,201		55.45
Vested	(83,571	)	32.13
Canceled	(516	)	56.25
Nonvested RSAs at March 31, 2018	605,163		$	48.05