Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Accounting Policies [Abstract]

Schedule of Estimated Useful Lives

Estimated useful lives by major asset category are as follows:

Manufacturing equipment	10 years
Laboratory equipment	7 years
Furniture and fixtures	5 years
Software and computer equipment	3 years
Leasehold improvements	Lower of estimated useful life or term of lease

Property, plant and equipment, net consists of the following:

(in thousands)	MARCH 31, 2018			DECEMBER 31, 2017
Manufacturing equipment	$	2,102		$	2,082
Laboratory equipment	4,278			3,602
Furniture and fixtures	1,273			1,209
Software and computer equipment	2,168			1,932
Leasehold improvements	2,012			1,887
Construction-in-progress	39,499			24,228
	51,332			34,940
Less: Accumulated depreciation	(3,522		)	(3,008		)
Total property, plant and equipment, net	$	47,810		$	31,932

Schedule of Computation of Diluted EPS

The potential common stock equivalents that have been excluded from the computation of Diluted EPS consist of the following:

	THREE MONTHS ENDED   MARCH 31,
	2018	2017
2014 Convertible Notes	5,040,323	5,040,323
Outstanding stock options	7,125,947	5,708,215
Stock purchase warrants	157,500	157,500
Nonvested restricted stock awards	605,163	348,660
Total	12,928,933	11,254,698