Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2017

Accounting Policies [Abstract]

Schedule of Estimated Useful Lives

Estimated useful lives by major asset category are as follows:

Manufacturing equipment	10 years
Laboratory equipment	7 years
Furniture and fixtures	5 years
Software and computer equipment	3 years
Leasehold improvements	Lower of estimated useful life or term of lease

and equipment, net consists of the following:

(in thousands)	DECEMBER 31,
	2017			2016
Manufacturing equipment	$	2,082		$	1,689
Laboratory equipment	3,602			2,537
Furniture and fixtures	1,209			808
Software and computer equipment	1,932			1,732
Leasehold improvements	1,887			641
Construction-in-progress	24,228			2,695
	34,940			10,102
Less: Accumulated depreciation	(3,008		)	(2,245		)
	$	31,932		$	7,857

Schedule of Computation of Diluted EPS

The potential common stock equivalents that have been excluded from the computation of Diluted EPS consist of the following:

	DECEMBER 31,
	2017	2016	2015
2014 Convertible Notes	5,040,323	5,040,323	5,040,323
Outstanding stock options	6,457,343	5,255,930	4,583,586
Stock purchase warrants	157,500	157,500	157,500
Nonvested restricted stock awards	447,049	164,194	119,993