Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2017

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Stock-Based Compensation Expense for Options Granted, Restricted Stock and Stock Purchase Rights as Reflected in Statement of Operations

Stock-based compensation expense for options granted and restricted stock awards (“RSAs”) is reflected in the consolidated statements of operations and comprehensive loss as follows:

	THREE MONTHS ENDED   MARCH 31,
(in thousands)	2017		2016
Research and development	$	1,064	$	712
Selling, general and administrative	3,786		2,822
Total	$	4,850	$	3,534

Schedule of Stock Options Activity

The following table summarizes the stock option activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE EXERCISE PRICE		WEIGHTED AVERAGE REMAINING CONTRACTUAL LIFE (YEARS)	AGGREGATE INTRINSIC VALUE (000’s)
Options outstanding at December 31, 2016	5,255,930		$	14.34
Granted	643,059		43.71
Exercised	(173,203	)	9.75
Canceled	(17,571	)	34.34
Options outstanding at March 31, 2017	5,708,215		$	17.73	7.5	$	157,690
Options exercisable at March 31, 2017	3,406,018		$	11.32	6.7	$	115,894

Restricted Stock and Restricted Stock Units Activity

The following table summarizes the RSA activity under the Plans:

	NUMBER OF SHARES		WEIGHTED AVERAGE FAIR VALUE PER SHARE
RSAs outstanding at December 31, 2016	164,194		$	19.87
Granted	229,493		44.38
Vested	(42,691	)	20.75
Canceled	(2,336	)	43.90
RSAs outstanding at March 31, 2017	348,660		$	35.74