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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, restricted stock awards (“RSAs”), RSAs with non-market performance and service conditions (“PSAs”), restricted stock units (“RSUs”), and stock appreciation rights (“SARs”) is reflected in the condensed consolidated statements of operations and comprehensive loss as follows:
 THREE MONTHS ENDED 
SEPTEMBER 30,		NINE MONTHS ENDED 
SEPTEMBER 30,
(in thousands)2022202120222021
Cost of goods sold$140 $287 $372 $1,225 
Selling, general, and administrative2,490 4,385 8,260 16,238 
Research and development1,012 1,941 3,600 5,895 
Total$3,642 $6,613 $12,232 $23,358 
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED
 AVERAGE EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 2021
6,550,610 $26.87 
Granted1,160,275 8.39 
Exercised(204,227)3.81 
Canceled/Expired(1,752,766)28.09 
Options outstanding at September 30, 2022
5,753,892 $23.59 6.32$12,896 
Options exercisable at September 30, 2022
3,654,873 $30.61 4.75$2,572 
Options vested and expected to vest at September 30, 2022
5,753,892 $23.59 6.32$12,896 
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSA, including PSA, activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSAs at December 31, 2021
977,244 $18.32 
Granted963,062 8.42 
Vested(266,519)25.51 
Canceled(181,999)18.72 
Non-vested RSAs at September 30, 2022
1,491,788 10.60 
The following table summarizes the RSU activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Non-vested RSUs at December 31, 2021
156,873 $14.88 
Granted148,850 8.33 
Vested(37,375)9.11 
Canceled(42,663)14.98 
Non-vested RSUs at September 30, 2022
225,685 11.49 
Schedule of Stock Appreciation Rights
The following table summarizes the SARs activity under the Plans:
NUMBER OF
SHARES		WEIGHTED 
AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2021
238,349 $27.67 
Granted111,854 8.21 
Exercised(1,425)12.25 
Canceled(44,201)25.95 
SARs outstanding at September 30, 2022
304,577 $20.84 3.2$852 
SARs exercisable at September 30, 2022
116,437 $34.27 1.7$42