Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net loss	$ (55,262)	$ (80,652)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities
Depreciation	3,152	3,161
Amortization and accretion	3,884	14,948
Stock-based compensation	8,590	16,745
Other non-cash	(324)	1,320
Changes in operating assets and liabilities
Accounts receivable, net	747	(3,129)
Inventory	(6,024)	(3,173)
Prepaid, current, and other assets	4,799	(2,532)
Licensing receivable	90,000	0
Accounts payable, accrued expenses, and other current liabilities	(4,839)	4,082
Operating lease liabilities	(2,168)	(2,934)
Deferred revenue	6,123	1,970
Net cash provided by (used in) operating activities	48,678	(50,194)
Cash flows from investing activities
Purchase of available-for-sale investments	(104,488)	(73,006)
Proceeds from sales and maturities of investments	61,222	52,988
Purchase of property, plant, and equipment	(2,966)	(1,377)
#REF!	(46,232)	(21,395)
Cash flows from financing activities
Payments related to issuance of stock for stock-based compensation arrangements, net	(191)	(25)
Net cash used in financing activities	(191)	(25)
Net change in cash and cash equivalents	2,255	(71,614)
Cash and cash equivalents, at beginning of period	37,187	151,570
Cash and cash equivalents, at end of period	39,442	79,956
Non-cash investing and financing activities
Purchase of property, plant, and equipment in accounts payable and accrued expenses and other current liabilities	$ 582	$ 727