Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities
Net loss	$ (35,891)	$ (41,964)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation	1,604	1,499
Amortization and accretion	2,007	7,408
Stock-based compensation	4,632	8,749
Other non-cash	(50)	1,116
Changes in operating assets and liabilities
Accounts receivable, net	5,211	9,872
Inventory	538	(1,052)
Prepaid, current and other assets	(1,211)	(4,286)
Licensing receivable	90,000	0
Accounts payable, accrued expenses and other current liabilities	(9,517)	(10,297)
Operating lease liabilities	(1,097)	(1,846)
Deferred revenue	5,685	747
Net cash provided by (used in) operating activities	61,911	(30,054)
Cash flows from investing activities
Purchase of available-for-sale investments	(70,308)	(25,236)
Proceeds from sales and maturities of investments	29,605	28,288
Purchase of property, plant and equipment	(1,597)	(772)
Net cash (used in) provided by investing activities	(42,300)	2,280
Cash flows from financing activities
Payments related to issuance of stock for stock-based compensation arrangements, net	(357)	(1,101)
Net cash used in financing activities	(357)	(1,101)
Net change in cash and cash equivalents	19,254	(28,875)
Cash and cash equivalents, at beginning of period	37,187	151,570
Cash and cash equivalents, at end of period	56,441	122,695
Non-cash investing and financing activities
Purchase of property, plant and equipment in accounts payable and accrued expenses and other current liabilities	$ 742	$ 182