Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash flows from operating activities
Net loss	$ (74,810)	$ (183,101)	$ (199,581)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation	6,399	6,366	5,138
Amortization and accretion	31,101	27,792	12,976
Acquisition of assets expensed to research and development	0	0	10,171
Stock-based compensation	29,524	40,095	45,093
Other non-cash	1,194	(732)	(271)
Changes in operating assets and liabilities
Accounts receivable, net	(12,806)	(17,668)	(35,639)
Inventory	(12,101)	(5,166)	(10,257)
Prepaid, current and other assets	(7,285)	340	(2,144)
Licensing receivable	(90,000)	0	0
Accounts payable, accrued expenses and other current liabilities	21,580	22,536	28,766
Operating lease liabilities	(5,407)	(6,010)	(4,682)
Deferred revenue	13,457	50,858	0
Net cash used in operating activities	(99,154)	(64,690)	(150,430)
Cash flows from investing activities
Acquisition of assets	0	0	(7,835)
Purchase of available-for-sale investments	(132,361)	(116,591)	(165,454)
Proceeds from sales and maturities of investments	117,451	192,870	0
Purchase of property, plant and equipment	(3,291)	(3,100)	(9,958)
Net cash (used in) provided by investing activities	(18,201)	73,179	(183,247)
Cash flows from financing activities
Proceeds from loan	0	8,274	0
Repayment of loan	0	(8,274)	0
Proceeds related to issuance of common stock for stock-based compensation arrangements, net	2,972	(859)	684
Proceeds from exercise of warrants	0	0	761
Proceeds from convertible notes, net of issuance costs	0	0	308,349
Payments of issuance costs	0	0	(1,769)
Payment for capped call options	0	0	(32,890)
Other financing	0	0	(336)
Net cash provided by (used in) financing activities	2,972	(859)	274,799
Net change in cash and cash equivalents	(114,383)	7,630	(58,878)
Cash and cash equivalents, at beginning of period	151,570	143,940	202,818
Cash and cash equivalents, at end of period	37,187	151,570	143,940
Supplemental disclosures
Cash paid for interest	4,744	5,034	6,496
Cash paid for income taxes	0	4,987	0
Non-cash investing and financing activities:
Liabilities incurred from Avizorex Asset Acquisition	0	0	1,186
Purchases of property, plant and equipment in accounts payable and accrued expense and other current liabilities	$ 922	$ 374	$ 771