Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Total revenues, net	$ 194,134	$ 83,138	$ 69,888
Costs and expenses:
Cost of goods sold	26,846	25,333	4,833
Selling, general and administrative	137,805	137,184	138,402
Pre-approval commercial manufacturing	0	2,304	22,767
Research and development	75,837	74,007	91,378
Total costs and expenses	240,488	238,828	257,380
Loss from operations	(46,354)	(155,690)	(187,492)
Other expense, net	(27,863)	(22,166)	(12,179)
Loss before income taxes	(74,217)	(177,856)	(199,671)
Income tax expense (benefit)	593	5,245	(90)
Net loss	$ (74,810)	$ (183,101)	$ (199,581)
Net loss per common share - diluted (in dollars per share)	$ (1.61)	$ (3.99)	$ (4.39)
Net loss per common share - basic (in dollars per share)	$ (1.61)	$ (3.99)	$ (4.39)
Weighted average number of common shares outstanding—diluted (in shares)	46,336,346	45,897,255	45,427,154
Weighted average number of common shares outstanding—basic (in shares)	46,336,346	45,897,255	45,427,154
Net loss	$ (74,810)	$ (183,101)	$ (199,581)
Unrealized (loss) gain on available-for-sale investments	(74)	40	(92)
Comprehensive loss	(74,884)	(183,061)	(199,673)
Product revenues, net
Total revenues, net	112,134	83,138	69,888
Licensing revenues
Total revenues, net	$ 82,000	$ 0	$ 0