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- Definition

Amount Receivable, Upon Execution of Collaboration Agreement

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Number Of FDA Approved Products

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[Line Items] for Organization, Consolidation and Presentation of Financial Statements [Table]

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Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable.

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- Definition

Face (par) amount of debt instrument at time of issuance.

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Contractual interest rate for funds borrowed, under the debt agreement.

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Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues.

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The Company (Details)	12 Months Ended
The Company (Details)	Dec. 31, 2021 USD ($) segment product	Dec. 31, 2020 USD ($)	Oct. 31, 2020 USD ($)	Sep. 30, 2019 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Number of operating segments \| segment	1
Number U.S. FDA approved products \| product	2
Upfront payment receivable	$ 88,000,000
Cash, cash equivalents and investments	139,801,000	$ 240,364,000
Collaborative Arrangement
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Supplemental upfront payment receivable	2,000,000
Second Santen Agreement \| Santen
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Upfront payment receivable	88,000,000		$ 50,000,000
Supplemental upfront payment receivable	2,000,000
Convertible Senior Notes Due 2024 \| Convertible debt
Organization, Consolidation and Presentation of Financial Statements [Line Items]
Principal amount	$ 316,250,000	$ 316,250,000		$ 316,250,000
Debt instrument, interest rate percentage				1.50%