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Stock-based Compensation (Tables)
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
Stock-based compensation expense for options granted, RSAs, PSAs, RSUs, SARs and stock purchase rights is reflected in the consolidated statements of operations and comprehensive loss as follows:
YEAR ENDED DECEMBER 31,
(in thousands)202120202019
Cost of goods sold$1,335 $2,353 $— 
Selling, general and administrative20,616 27,176 30,463 
Pre-approval commercial manufacturing— 344 3,634 
Research and development7,573 10,222 10,996 
Total$29,524 $40,095 $45,093 
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions
Weighted average assumptions utilized in the fair value calculation for options to purchase common stock as of December 31, 2021, 2020 and 2019 are as follows: 
 YEAR ENDED
DECEMBER 31,
 202120202019
Expected term (years)6.06.06.0
Expected stock price volatility68 %74 %74 %
Risk-free interest rate1.0 %0.9 %1.9 %
Dividend yield— %— %— %
Schedule of Stock Options Activity
The following table summarizes the stock option activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
Options outstanding at December 31, 2020
8,588,614 $27.36 
Granted1,614,997 13.92 
Exercised(1,146,095)3.20 
Canceled(2,506,906)31.02 
Options outstanding at December 31, 2021
6,550,610 $26.87 6.4$1,116 
Options exercisable at December 31, 2021
4,449,867 $31.05 5.2$1,116 
Options vested and expected to vest at December 31, 2021
6,550,610 $26.87 6.4$1,116 
Schedule of Stock Options Outstanding and Exercisable Option Plans
The following table provides additional information about stock options that are outstanding and exercisable at December 31, 2021:
EXERCISE
PRICE		OPTIONS
OUTSTANDING		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		OPTIONS
EXERCISABLE
$0.20 - $10.00
735,309 6.7288,083 
$10.01 - $20.00
2,035,383 7.5959,566 
$20.01 - $30.00
1,794,790 5.31,391,071 
$30.01 - $45.00
700,678 5.7628,032 
$45.01 - $55.00
753,011 6.2682,273 
$55.01 - $73.10
531,439 6.2500,842 
6,550,610 4,449,867 
Schedule of Share-based Compensation, Restricted Stock and Restricted Stock Units Activity
The following table summarizes the RSA, including PSAs, activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Nonvested RSAs at December 31, 2020
809,527 $29.03 
Granted660,926 13.48 
Vested(274,488)33.70 
Canceled(218,721)24.03 
Nonvested RSAs at December 31, 2021
977,244 $18.32 
NUMBER OF
SHARES		WEIGHTED AVERAGE
FAIR VALUE PER SHARE
Nonvested RSUs at December 31, 2020
107,182 $14.43 
Granted100,322 15.48 
Vested(30,958)15.27 
Canceled(19,673)14.89 
Nonvested RSUs at December 31, 2021
156,873 $14.88 
Schedule of Stock Appreciation Rights
The following table summarizes the SARs activity under the Plans:
NUMBER OF
SHARES		WEIGHTED AVERAGE
EXERCISE PRICE		WEIGHTED
AVERAGE
REMAINING
CONTRACTUAL
LIFE (YEARS)		AGGREGATE
INTRINSIC
VALUE
(000’s)
SARs outstanding at December 31, 2020
212,044 $32.28 
Granted70,700 15.97 
Exercised— — 
Canceled(44,395)31.05 
SARs outstanding at December 31, 2021
238,349 $27.67 3.04$— 
SARs exercisable at December 31, 2021
83,873 $38.63 2.11$—