X0306 4 2022-07-01 0 0001337553 AERIE PHARMACEUTICALS INC AERI 0001892279 Calabrese Jeffrey C/O AERIE PHARMACEUTICALS, INC. 4301 EMPEROR BLVD., SUITE 400 DURHAM NC 27703 0 1 0 0 Vice President of Finance Common Stock 2022-07-01 4 A 0 11276 0.00 A 19295 D Stock Option (right to buy) 8.36 2022-07-01 4 A 0 20774 0.00 A 2032-07-01 Common Stock 20774 20774 D These shares of Common Stock are scheduled to vest, subject to the reporting person's continued employment with the issuer through the applicable vesting date, in equal installments on each of the first four anniversaries of July 1, 2022. This Option is scheduled to vest, subject to the reporting person's continued employment with the issuer through the applicable vesting date, in equal installments on each of the first 48 monthly anniversaries of July 1, 2022. /s/ John W. LaRocca, Attorney-in-Fact for Jeffrey Calabrese 2022-07-06