Topline Results from Rhopressa (netarsudil ophthalmic solution) 0.02% Phase 4 Multi-center Open-label Study (MOST) November 6, 2019 For Investor Use Exhibit 99.1
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Efficacy Summary for MOST Study 12-week MOST study evaluated efficacy, tolerability and safety of Rhopressa use in 260 patients in a real-world clinical setting Use of Rhopressa as monotherapy or adjunct was at discretion of the physician Used adjunctively (n=151, mITT): Rhopressa was similarly effective when added to prior PGA monotherapy or when added to prior multi-drug therapy Additional IOP reductions of 4.3 mmHg and 4.5 mmHg, respectively (12 weeks) Used as monotherapy (n=91, mITT): Rhopressa maintained IOP levels comparable to prior PGA following switch (n=57) Rhopressa was well tolerated as monotherapy and adjunctive therapy No treatment-related serious adverse events (AEs) Most common AEs were Conjunctival Hyperemia (20.8%) and Vision Blurred (7.3%) 89% of patients reported Rhopressa was tolerated “well” or better in survey (mITT) For Investor Use
Rhopressa Multi-center Open-label Study (MOST) 12-week, prospective, multi-center, non-comparative, open-label 260 subjects diagnosed with open-angle glaucoma (OAG) or ocular hypertension (OHT) Primary Endpoint: Percent change from baseline (BL) in mean IOP at Week 12 Secondary Endpoints: Change from BL in mean IOP at Week 12 Mean IOP at Week 12 BL OAG or OHT (n=260) Rhopressa as Monotherapy (n=99) Rhopressa as adjunctive therapy (n=161) WK 6 WK12 For Investor Use
Rhopressa Added to Previous Therapy Rhopressa provided consistent IOP reductions whether added to prior PGA monotherapy (-4.3 mmHg) or prior combination therapy (-4.5 mmHg) Adjunct Therapy Treatment Group Baseline Week 6 Week 12 Rhopressa + PGA (n=55) Mean IOP (mmHg) 21.1 17.0 16.9 Δ from BL (mmHg) -- -4.1 (-19.0%) -4.3 (-20.2%) Rhopressa + ≥2 Meds (n=64) Mean IOP (mmHg) 20.6 16.9 16.2 Δ from BL (mmHg) -- -3.7 (-17.5%) -4.5 (-20.9%) For Investor Use Note: Excludes patients where a prior medication was switched out for Rhopressa
Subjects On PGA Monotherapy Switched to Rhopressa Monotherapy Monotherapy Treatment Group Baseline Week 6 Week 12 PGA Switched to Rhopressa (n=57) Mean IOP (mmHg) 18.2 17.4 17.5 Δ from BL (mmHg) -- -0.8 (-3.2%) -0.6 (-2.5%) Switch to Rhopressa monotherapy provided similar efficacy to prior PGA monotherapy For Investor Use
Adverse Events DC: Discontinuation Adverse Events Rhopressa as Monotherapy N=99 Rhopressa as Adjunct N= 161 Adverse Events (≥ 5%) Conjunctival hyperemia 22 (22.2%) 32 (19.9%) Vision blurred 9 (9.1%) 10 (6.2%) Conjunctival hemorrhage 6 (6.1%) 8 (5.0%) Instillation site pain 6 (6.1%) 8 (5.0%) Adverse Events Leading to DC (≥ 2%) Vision Blurred 5 (5.1%) 3 (1.9%) Eye pruritis 2 (2.0%) 1 (0.6%) Conjunctival hyperemia 1 (1.0%) 7 (4.3%) There were no treatment-related serious adverse events 10.6% – 12.1% of subjects discontinued due to adverse events For Investor Use
Patient Reported Tolerance (WK 12 or exit visit) Overall N= 238 Previously Treatment Naïve N=24 Rhopressa Switches N= 66 Adjunct Therapy N=148 Very well 45.0% 50.0% 37.9% 47.3% Mostly well 23.9% 16.7% 28.8% 23.0% Well 20.2% 25.0% 22.7% 18.2% Very Little 8.0% 4.2% 10.6% 7.4% Not able to tolerate 2.9% 4.2% 0% 4.1% 91.7% 89.4% 88.5% Rated as “Well” or better 89.1% How well are you able to tolerate the study eye medication? For Investor Use
Summary for MOST Study 12-week MOST study evaluated Rhopressa use in 260 patients in a real world clinical setting Used adjunctively (n=151, mITT): Rhopressa was similarly effective when added to prior PGA monotherapy or when added to prior multi-drug therapy Used as monotherapy (n=91, mITT): Rhopressa maintained IOP levels comparable to prior PGA monotherapy following switch (n=57) Rhopressa was well tolerated as monotherapy and adjunctive therapy 89% of patients reported Rhopressa was tolerated “well” or better in survey For Investor Use