SCHEDULE 13G/A 0001535264 XXXXXXXX LIVE 9 Common Stock 03/31/2025 0001337013 InfuSystem Holdings, Inc 45685K102 3851 WEST HAMLIN ROAD ROCHESTER HILLS MI 48309 Rule 13d-1(b) AWM Investment Company, Inc. DE 1626280.00 1626280.00 1626280.00 7.7 IA AWM Investment Company, Inc., a Delaware corporation (AWM), is the investment adviser to Special Situations Life Sciences Fund, L.P. (SSLS) (SSLS will hereafter be referred to as the Fund). As the investment adviser to the Fund, AWM holds sole voting and investment power over 1,626,280 Shares held by SSLS. InfuSystem Holdings, Inc 3851 WEST HAMLIN ROAD, ROCHESTER HILLS, MICHIGAN, 48309 The person filing this report is AWM Investment Company, Inc., a Delaware corporation (AWM), which is the investment adviser to Special Situations Life Sciences Fund, L.P. a Delaware limited partnership (SSLS). The principal business of the Fund is to invest in equity and equity-related securities and other securities of any kind or nature. David M. Greenhouse (Greenhouse) and Adam C. Stettner (Stettner) are members of LS Advisers, L.LC., a New York limited liability company (LS). Greenhouse and Stettner are also controlling principals of AWM. 527 Madison Avenue, Suite 2600 New York, NY 10022 AWM is a Delaware Corporation Y 1,626,280 7.7 AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole voting power over 1,626,280 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM. AWM is the investment adviser to the Fund. As the investment adviser to the Fund, AWM holds sole investment power over 1,626,280 shares of Common Stock of the Issuer (the Shares) held by SSLS. Greenhouse and Stettner are members of LS, the general partner of SSLS. Greenhouse and Stettner are also controlling principals of AWM. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. AWM Investment Company, Inc. Adam Stettner 05/09/2025