X0306 4 2022-02-17 0 0001337013 InfuSystem Holdings, Inc INFU 0001519525 Sansone Christopher R. C/O INFUSYSTEM HOLDINGS, INC. 3851 WEST HAMLIN ROAD ROCHESTER HILLS MI 48309 1 0 0 0 Common Stock 2022-02-17 4 M 0 25000 1.98 A 25000 D Common Stock 1464916 I See Common Stock 228118 I See Stock Option (right to buy) 1.98 2022-02-17 4 M 0 25000 0 D 2022-09-07 Common Stock 25000 0 D The reported securities are directly owned by Sansone Partners, L.P., a Delaware limited partnership. The Reporting Person is the managing member of (i) the general partner of this limited partnership and (ii) the investment manager of this limited partnership and, as such, may be deemed to indirectly beneficially own the shares held by this limited partnership. The Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. The reported securities are directly owned by Sansone Partners (QP), L.P., a Delaware limited partnership. The Reporting Person is the managing member of (i) the general partner of this limited partnership and (ii) the investment manager of this limited partnership and, as such, may be deemed to indirectly beneficially own the shares held by this limited partnership. The Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. The options, representing the right to purchase a total of 25,000 shares of InfuSystem Holdings, Inc. common stock, vested in twelve monthly installments beginning October 7, 2017. /s/ Kevin Whitman, Attorney-in-Fact for Christopher R. Sansone 2022-02-22