X0306 4 2021-03-22 0 0001337013 InfuSystem Holdings, Inc INFU 0001376620 Lehman Gregg Owen 3851 WEST HAMLIN ROAD ROCHESTER HILLS MI 48309 1 0 0 0 Common Stock 2021-03-22 4 M 0 21179 2.39 A 21525 D Common Stock 2021-03-22 4 S 0 21179 22.04 D 346 D Common Stock 2021-03-23 4 M 0 9708 2.39 A 10054 D Common Stock 2021-03-23 4 S 0 9708 21.2 D 346 D Common Stock 2021-03-24 4 M 0 19113 2.39 A 19459 D Common Stock 2021-03-24 4 S 0 19113 20.74 D 346 D Stock Option (right to buy) 2.39 2021-03-22 4 M 0 21179 0 D 2017-02-18 2027-01-18 Common Stock 21179 38821 D Stock Option (right to buy) 2.39 2021-03-23 4 M 0 9708 0 D 2017-02-18 2027-01-18 Common Stock 9708 9708 D Stock Option (right to buy) 2.39 2021-03-24 4 M 0 19113 0 A 2017-02-18 2027-01-18 Common Stock 19113 10000 D The price reported in Column 4 is a weighted average price. These shares reported herein were sold in multiple transactions. The reporting person undertakes to provide to the Issuer, and security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. /s/Kevin Whitman, Attorney-in-Fact for Gregg O. Lehman 2021-03-24