<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002002273</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001336920</issuerCik>
      <issuerName>Leidos Holdings, Inc.</issuerName>
      <secFileNumber>001-33072</secFileNumber>
      <issuerAddress>
        <com:street1>1750 PRESIDENTS STREET</com:street1>
        <com:city>RESTON</com:city>
        <com:stateOrCountry>VA</com:stateOrCountry>
        <com:zipCode>20190</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>571-526-6000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hull Stephen Edward</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Sector President </relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock </securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Citigroup Global Markets, Inc.</name>
        <address>
          <com:street1>390 Greenwich St</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10013</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>12497</noOfUnitsSold>
      <aggregateMarketValue>2227590.00</aggregateMarketValue>
      <noOfUnitsOutstanding>128297332</noOfUnitsOutstanding>
      <approxSaleDate>09/04/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock </securitiesClassTitle>
      <acquiredDate>09/04/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting/Stock Option Exercise </natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Leidos </nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>12497</amountOfSecuritiesAcquired>
      <paymentDate>09/04/2025</paymentDate>
      <natureOfPayment>Cash/Services Rendered </natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Stephen Hull </name>
        <address>
          <com:street1>1750 Presidents Street</com:street1>
          <com:city>Reston </com:city>
          <com:stateOrCountry>VA</com:stateOrCountry>
          <com:zipCode>20190</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock </securitiesClassTitle>
      <saleDate>08/08/2025</saleDate>
      <amountOfSecuritiesSold>7526</amountOfSecuritiesSold>
      <grossProceeds>1327477.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Stephen Hull</name>
        <address>
          <com:street1>1750 Presidents Street</com:street1>
          <com:city>Reston</com:city>
          <com:stateOrCountry>VA</com:stateOrCountry>
          <com:zipCode>20190</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/20/2025</saleDate>
      <amountOfSecuritiesSold>12890</amountOfSecuritiesSold>
      <grossProceeds>2297945.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Stock exercise was cashless exercise placed for 2,827 options where taxes were held for obligation </remarks>
    <noticeSignature>
      <noticeDate>09/04/2025</noticeDate>
      <signature>Conformed Signature On File </signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
