<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001512157</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001336920</issuerCik>
      <issuerName>Leidos Holdings, Inc.</issuerName>
      <secFileNumber>001-33072</secFileNumber>
      <issuerAddress>
        <com:street1>1750 PRESIDENTS STREET</com:street1>
        <com:city>RESTON</com:city>
        <com:stateOrCountry>VA</com:stateOrCountry>
        <com:zipCode>20190</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>571-526-6000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kovarik Robert C JR</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
        <relationshipToIssuer>Former Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Citigroup Global Markets, Inc.</name>
        <address>
          <com:street1>390 Greenwich St.</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10013</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2486</noOfUnitsSold>
      <aggregateMarketValue>384668.59</aggregateMarketValue>
      <noOfUnitsOutstanding>128718872</noOfUnitsOutstanding>
      <approxSaleDate>05/08/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>04/26/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Leidos</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1574</amountOfSecuritiesAcquired>
      <paymentDate>05/08/2025</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/05/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Leidos</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>912</amountOfSecuritiesAcquired>
      <paymentDate>05/08/2025</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Robert C Kovarik Jr</name>
        <address>
          <com:street1>1750 Presidents Street</com:street1>
          <com:city>Reston</com:city>
          <com:stateOrCountry>VA</com:stateOrCountry>
          <com:zipCode>20190</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/13/2025</saleDate>
      <amountOfSecuritiesSold>1511</amountOfSecuritiesSold>
      <grossProceeds>203322.12</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/08/2025</noticeDate>
      <signature>Conformed Signature on File</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
