<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001222671</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001336920</issuerCik>
      <issuerName>Leidos Holdings, Inc.</issuerName>
      <secFileNumber>001-33072</secFileNumber>
      <issuerAddress>
        <com:street1>1750 PRESIDENTS STREET</com:street1>
        <com:city>RESTON</com:city>
        <com:stateOrCountry>VA</com:stateOrCountry>
        <com:zipCode>20190</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>571-526-6000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>MOHAPATRA SURYA N</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Georgeson Securities Corp</name>
        <address>
          <com:street1>144 Fernwood Ave</com:street1>
          <com:city>EDISON</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>08837</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2748</noOfUnitsSold>
      <aggregateMarketValue>535748.29</aggregateMarketValue>
      <noOfUnitsOutstanding>133433109</noOfUnitsOutstanding>
      <approxSaleDate>11/07/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>11/07/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Option Exercise and Sale</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Leidos Holdings Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4070</amountOfSecuritiesAcquired>
      <paymentDate>11/07/2024</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/07/2024</noticeDate>
      <signature>Conformed Signature on File</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
