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Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Year</td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48E_eecd--PeoTotalCompAmt_zrKl3LtExeh7" style="border-bottom: Black 1pt solid; text-align: center">Summary Compensation Table Total for PEO (1)</td><td style="padding-bottom: 1pt"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48B_eecd--PeoActuallyPaidCompAmt_zXIoanwcgAHb" style="border-bottom: Black 1pt solid; text-align: center">Compensation Actually Paid to PEO (2)</td><td style="padding-bottom: 1pt"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_48F_eecd--NonPeoNeoAvgTotalCompAmt_zOLDTuBjWFZ5" style="border-bottom: Black 1pt solid; text-align: center">Average Summary Compensation Table Total for Non-PEO NEO’s (3)</td><td style="padding-bottom: 1pt"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_482_eecd--NonPeoNeoAvgCompActuallyPaidAmt_zCfJsrnMnOZ8" style="border-bottom: Black 1pt solid; text-align: center">Average Compensation Actually Paid to Non-PEO NEO’s (2)</td><td style="padding-bottom: 1pt"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_484_eecd--TotalShareholderRtnAmt_pid_zzYjKPGkvIli" style="border-bottom: Black 1pt solid; text-align: center">Value of Initial Fixed $100 Investment Based On Total Shareholder Return (4)</td><td style="padding-bottom: 1pt"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" id="xdx_486_eus-gaap--NetIncomeLoss_z7sI0YWzNiYc" style="border-bottom: Black 1pt solid; text-align: center">Net Income (Loss) (5)</td><td style="padding-bottom: 1pt"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td></tr> <tr id="xdx_412_20240101__20241231_zyAIKPDPpuh8" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 40%; text-align: center">2024</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">153,495</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">94,461</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">562,383</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">542,516</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">17.06</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 6%; text-align: right">(3,585,965</td><td style="width: 1%; text-align: left">)</td></tr> <tr id="xdx_418_20230101__20231231_zogWsACBDsOe" style="vertical-align: bottom; background-color: White"> <td style="text-align: center">2023</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">634,565</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">669,196</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">550,000</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">453,624</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">19.75</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(5,087,029</td><td style="text-align: left">)</td></tr> <tr id="xdx_415_20220101__20221231_zgZ9LQcDvi9d" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: center">2022</td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">315,640</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">315,528</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">725,739</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">647,694</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">42.86</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left">$</td><td style="text-align: right">(6,312,535</td><td style="text-align: left">)</td></tr> </table> 153495 94461 562383 542516 17.06

-3585965

634565 669196 550000 453624 19.75

-5087029

315640 315528 725739 647694 42.86

-6312535

<table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%"> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"> </td> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">(1)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The amounts presented reflect the total compensation set forth in the Summary Compensation Table (“SCT”) for the Company’s former CEO, Dr. John S. Kovach, and the successor CEO, Bas van der Baan, who were the Company’s PEO’s during the years ended December 31, 2024, 2023 and 2022. Dr. Kovach terminated the position of CEO, and Mr. Baan was appointed the successor on September 26, 2023. Mr. Baan terminated the position of CEO, and Geordan Pursglove was appointed his successor effective June 16, 2025.</td></tr> </table> Dr. John S. Kovach Dr. John S. Kovach Dr. John S. Kovach Bas van der Baan Bas van der Baan Bas van der Baan <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%"> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"> </td> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">(2)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The following table reflects the adjustments necessary, each of which is prescribed by SEC rule, to calculate the Compensation Actually Paid (“CAP”) from those total amounts reflected in the SCT. The SCT amounts and the CAP amounts do not reflect the actual amount of compensation earned by or paid to the Company’s executives during the applicable years but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. To determine CAP, the adjustments below were made to the Company’s executive officer’s total compensation.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; border-collapse: collapse; width: 100%"> <tr style="display: none; vertical-align: bottom"> <td> </td><td> </td> <td colspan="2" id="xdx_497_20240101__20241231__ecd--IndividualAxis__ecd--PeoMember_zXegRjquGJ24"> </td><td> </td><td> </td> <td colspan="2" id="xdx_495_20240101__20241231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zQ04ULnVg089"> </td><td> </td><td> </td> <td colspan="2" id="xdx_49E_20230101__20231231__ecd--IndividualAxis__ecd--PeoMember_z8YFaUnMcSAl"> </td><td> </td><td> </td> <td colspan="2" id="xdx_49B_20230101__20231231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zEZV3EY6n697"> </td><td> </td><td> </td> <td colspan="2" id="xdx_498_20220101__20221231__ecd--IndividualAxis__ecd--PeoMember_zHO0cEvzD236"> </td><td> </td><td> </td> <td colspan="2" id="xdx_490_20220101__20221231__ecd--IndividualAxis__ecd--NonPeoNeoMember_zQTIyqVQZAe7"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2024</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2023</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">PEO’s</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; text-align: center">Other NEO’s</td><td style="padding-bottom: 1pt"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">PEO</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; text-align: center">Other NEO’s</td><td style="padding-bottom: 1pt"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">PEO</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; text-align: center">Other NEO’s</td><td style="padding-bottom: 1pt"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td><td> </td> <td colspan="2"> </td><td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="width: 40%; text-align: left">SCT Amounts</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_986_eecd--PeoTotalCompAmt_c20240101__20241231_zgebBe42Pbyj" style="width: 6%; text-align: right" title="PEO SCT Amounts">153,495</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_983_eecd--NonPeoNeoAvgTotalCompAmt_c20240101__20241231_zMjVMJSRGYS3" style="width: 6%; text-align: right" title="NEO SCT Amounts">562,383</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98E_eecd--PeoTotalCompAmt_c20230101__20231231_zAlbnbjd0GB1" style="width: 6%; text-align: right" title="PEO SCT Amounts">634,565</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98A_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zqLiZZin1vD1" style="width: 6%; text-align: right" title="NEO SCT Amounts">550,000</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98D_eecd--PeoTotalCompAmt_c20220101__20221231_zOwwLCz79zse" style="width: 6%; text-align: right" title="PEO SCT Amounts">315,640</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98E_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_zOvQqKvBz0hh" style="width: 6%; text-align: right" title="NEO SCT Amounts">725,739</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Adjustments Related to Defined Benefit and Actuarial Plans:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--AdjustmentsRelatedToDefinedBenefitAndActuarialPlansNoneMember_zDTtAy764uGa" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-indent: 13.5pt">None (6)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Adjustments Related to Stock-Based Compensation:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_401_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--ValuesReportedStockAwardsAndOptionAwardsColumnsOfSCTMember_z713L2HEvdh8" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 13.5pt">Values reported in Stock Awards and Option Awards columns of the SCT</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(29,074</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(403,066</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(65,640</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(196,920</td><td style="text-align: left">)</td></tr> <tr id="xdx_407_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--YearEndFairValueOfAwardsGrantedDuringTheYearThatAreOutstandingAndUnvestedAtEndOfYearMember_zJqUCsIHp6Vg" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 13.5pt">Year-end fair value of awards granted during the year that are outstanding and unvested at the end of the year</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">19,550</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">434,409</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">49,118</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">147,353</td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DecreaseInFairValueOfAwardsGrantedInPriorYearsAreOutstandingAndUnvestedAtYearEndMember_za4Wlw77GxCh" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 13.5pt">Decrease in fair value of awards granted in prior years that are outstanding and unvested at year-end</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(58,757</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(2,261</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(72,405</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(39,224</td><td style="text-align: left">)</td></tr> <tr id="xdx_40A_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--FairValueOfAwardsGrantedAndVestedDuringTheYearMember_zUiBclANSYJc" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 13.5pt">Fair value of awards granted and vested during the year</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">3,796</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">39,491</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">16,410</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">49,230</td><td style="text-align: left"> </td></tr> <tr id="xdx_409_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DecreaseInFairValueOfAwardsGrantedInPriorYearsThatVestedDuringTheYearMember_zFhu0ISDQaD5" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-left: 13.5pt">Decrease in fair value of awards granted in prior years that vested during the year</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(277</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(5,095</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(23,971</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(38,484</td><td style="text-align: left">)</td></tr> <tr id="xdx_40C_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DecreaseInFairValueOfAwardsGrantedInPriorYearsThatFailedToMeetVestingConditionsDuringYearMember_zkPLNJVVR1I1" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-left: 13.5pt">Decrease in fair value of awards granted in prior years that failed to meet vesting conditions during the year</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(6,783</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(36,203</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">—</td><td style="text-align: left"> </td></tr> <tr id="xdx_405_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsAndOtherEarningsPaidOnAwardsBeforeVestingDateMember_zZskVNLErO9j" style="vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 13.5pt">Dividends and other earnings paid on awards before the vesting date</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_400_eecd--AdjToCompAmt_hecd--AdjToCompAxis__custom--DividendsAndOtherEarningsPaidOnAwardsBeforeVestingDateMember_ztqqGGxiBZgi" style="display: none; vertical-align: bottom; background-color: rgb(204,238,255)"> <td style="text-align: left; padding-bottom: 1pt; padding-left: 13.5pt">Adjustment to Compensation Amount</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">—</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">CAP Amounts</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_987_eecd--PeoActuallyPaidCompAmt_c20240101__20241231_zkG9q172wMm5" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, PEO">94,461</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_980_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20240101__20241231_zniv9fJlWXm1" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, OTHER NEO">542,516</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_989_eecd--PeoActuallyPaidCompAmt_c20230101__20231231_zeqNzZJqOsai" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, PEO">669,196</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_983_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_zkwj9SxfnuV7" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, OTHER NEO">453,624</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_981_eecd--PeoActuallyPaidCompAmt_c20220101__20221231_zbAdXoK5hQw5" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, PEO">315,528</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_zsVANawWPXB8" style="border-bottom: Black 2.5pt double; text-align: right" title="CAP Amounts, OTHER NEO">647,694</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%"> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in"> </td> <td style="font: 10pt Times New Roman, Times, Serif; width: 0.25in">(3)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The amounts presented reflect the total compensation set forth in the SCT for the Company’s Non-PEO NEOs, James S. Miser, Robert N. Weingarten, Eric J. Forman and Jan H.M. Schellens, during the periods presented.</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify"> </td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif">(4)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The amounts presented reflect the value of a fixed investment of $100 on January 1st of the reporting period (i.e., January 1, 2022) based upon the closing market price of the Company’s common stock of $2.03, $2.35 and $5.10 at December 31, 2024, December 31, 2023 and December 31, 2022, respectively, as traded on The Nasdaq Capital Market. All amounts presented herein have been retroactively adjusted to reflect the 1-for-10 reverse split of the Company’s common stock effective June 2, 2023.</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify"> </td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif">(5)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The amounts presented reflect the net loss as reported in the Company’s audited financial statements for the periods presented.</td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify"> </td></tr> <tr style="font: 10pt Times New Roman, Times, Serif; vertical-align: top"> <td style="font: 10pt Times New Roman, Times, Serif"> </td> <td style="font: 10pt Times New Roman, Times, Serif">(6)</td> <td style="font: 10pt Times New Roman, Times, Serif; text-align: justify">The Company had no Defined Benefit or Actuarial Plans during the periods presented.</td></tr> </table> 153495 562383 634565 550000 315640 725739 -29074 -403066 -65640 -196920 19550 434409 49118 147353 -58757 -2261 -72405 -39224 3796 39491 16410 49230 -277 -5095 -23971 -38484 -6783 -36203 94461 542516 669196 453624 315528 647694 The amounts presented reflect the total compensation set forth in the Summary Compensation Table (“SCT”) for the Company’s former CEO, Dr. John S. Kovach, and the successor CEO, Bas van der Baan, who were the Company’s PEO’s during the years ended December 31, 2024, 2023 and 2022. Dr. Kovach terminated the position of CEO, and Mr. Baan was appointed the successor on September 26, 2023. Mr. Baan terminated the position of CEO, and Geordan Pursglove was appointed his successor effective June 16, 2025. The following table reflects the adjustments necessary, each of which is prescribed by SEC rule, to calculate the Compensation Actually Paid (“CAP”) from those total amounts reflected in the SCT. The SCT amounts and the CAP amounts do not reflect the actual amount of compensation earned by or paid to the Company’s executives during the applicable years but rather are amounts determined in accordance with Item 402 of Regulation S-K under the Exchange Act. To determine CAP, the adjustments below were made to the Company’s executive officer’s total compensation. The amounts presented reflect the total compensation set forth in the SCT for the Company’s Non-PEO NEOs, James S. Miser, Robert N. Weingarten, Eric J. Forman and Jan H.M. Schellens, during the periods presented. The amounts presented reflect the value of a fixed investment of $100 on January 1st of the reporting period (i.e., January 1, 2022) based upon the closing market price of the Company’s common stock of $2.03, $2.35 and $5.10 at December 31, 2024, December 31, 2023 and December 31, 2022, respectively, as traded on The Nasdaq Capital Market. All amounts presented herein have been retroactively adjusted to reflect the 1-for-10 reverse split of the Company’s common stock effective June 2, 2023. The amounts presented reflect the net loss as reported in the Company’s audited financial statements for the periods presented. The Company had no Defined Benefit or Actuarial Plans during the periods presented.