X0203 3 2010-01-20 0 0001335105 LIXTE BIOTECHNOLOGY HOLDINGS, INC. LIXT.OB 0001307796 SCHWARTZBERG DEBBIE 269 SOUTH BEVERLY DRIVE, NO. 1315 BEVERLY HILLS CA 90212 0 0 1 0 Common Stock 1504845 D Common Stock 684000 I by the Julie Schwartzberg Trust Common Stock 650000 I by the David N. Sterling Trust Common Stock 994700 I by spouse Warrant 0.5 2009-12-31 2012-12-31 Common Stock 1000000 D Warrant 0.75 2009-12-31 2012-12-31 Common Stock 1000000 D Warrant 0.5 2009-12-31 2012-12-31 Common Stock 500000 I by spouse Warrant 0.75 2009-12-31 2012-12-31 Common Stock 500000 I by spouse Warrant 0.5 2009-12-31 2012-12-31 Common Stock 500000 I by Julie Schwartzberg Trust Warrant 0.75 2009-12-31 2012-12-31 Common Sstock 500000 I by Julie Schwartzberg Trust Warrant 0.5 2009-12-31 2012-12-31 Common Stock 500000 I by David N. Sterling Trust Warrant 0.75 2009-12-31 2012-12-31 Common Stock 500000 I by David N. Sterling Trust Option 1 2007-09-12 2011-09-12 Common Stock 500000 I by spouse option 1 2008-09-12 2011-09-12 Common Stock 500000 I by spouse Option 1 2009-10-07 2013-09-12 Common Stock 500000 I by spouse Ms. Schwartzberg is a co-trustee of the Julie Schwartzberg Trust in which she shares voting, disposition and investment control over the securities. Ms. Schwartzberg is a co-trustee of the David N. Sterling Trust in which she shares voting, disposition and investment control over the securities. /s/ Debbie Schwartzberg 2010-02-01