X0306 4 2019-06-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001334365 Lee Yuchun C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2019-06-01 4 D 0 1801 D 4847 D Stock Option (Right to Buy) 168.04 2019-06-01 4 A 0 6659 0.00 A 2029-05-31 Common Stock 6659 6659 D Deferred Stock Units 2019-06-01 4 A 0 1801 A Common Stock 1801 1801 D Upon the vesting of restricted stock units granted to Mr. Lee on June 1, 2018, Mr. Lee deferred the receipt of 1,801 shares of common stock and received instead 1,801 deferred stock units pursuant to the Company's deferred compensation plan. As a result, Mr. Lee is reporting the disposition of 1,801 shares of common stock in exchange for an equal number of deferred stock units. Fully vested. Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Mr. Lee's service on our board of directors, (ii) a change of control of our company and (iii) Mr. Lee's disability or death. /s/ Omar White, Attorney-in-Fact 2019-06-04