X0303 4 2010-09-20 0001333763 Chelsea Therapeutics International, Ltd. CHTP 0001458177 VENROCK HEALTHCARE CAPITAL PARTNERS LP 3340 HILLVIEW AVENUE PALO ALTO CA 94304 0 0 1 0 0001479354 VHCP Co-Investment Holdings, LLC 3340 HILLVIEW AVENUE PALO ALTO CA 94304 0 0 1 0 0001479355 VHCP Management, LLC 3340 HILLVIEW AVENUE PALO ALTO CA 94304 0 0 1 0 0001365618 Hove Anders D C/O VENROCK 530 FIFTH AVENUE NEW YORK NY 10036 0 0 1 0 0001239242 ROBERTS BRYAN E C/O VENROCK 3340 HILLVIEW AVENUE PALO ALTO CA 94304 0 0 1 0 Common Stock 2010-09-20 4 S 0 83691 6.2995 D 3024253 I By Fund Common Stock 2010-09-20 4 S 0 15309 6.2995 D 553217 I By Fund Consists of shares of common stock held directly by Venrock Healthcare Capital Partners, L.P. ("VHCP LP"). VHCP Management, LLC ("VHCP Management") is the general partner of VHCP LP and may be deemed to beneficially own these shares. Messrs. Anders Hove and Bryan Roberts are the managing members of VHCP Management and may be deemed to beneficially own these shares. Each reporting person disclaims beneficial ownership of these shares, except to the extent of his or its respective pecuniary interest therein. Consists of shares of common stock held directly by Venrock Co-Investment Holdings, LLC ("Venrock Co-Investment"). VHCP Management is the manager of Venrock Co-Investment and may be deemed to beneficially own these shares. Messrs. Hove and Roberts are the managing members of VHCP Management and may be deemed to beneficially own these shares. Each reporting person disclaims beneficial ownership of these shares, except to the extent of his or its respective pecuniary interest therein. /s/ David L. Stepp, Authorized Signatory 2010-09-22 /s/ David L. Stepp, Authorized Signatory 2010-09-22 /s/ David L. Stepp, Authorized Signatory 2010-09-22 /s/ David L. Stepp, as attorney-in-fact 2010-09-22 /s/ David L. Stepp, as attorney-in-fact 2010-09-22