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Consolidated Statements Of Cash Flows (USD $)
12 Months Ended 117 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2011
Operating activities:        
Net loss $ (50,452,165) $ (37,330,069) $ (25,771,914) $ (183,325,501)
Adjustments to reconcile net loss to net cash used in operating activities:        
Non-cash stock-based compensation 2,648,741 1,986,755 1,673,165 8,990,656
Depreciation and amortization 116,465 75,610 69,431 421,979
Stock issued for license fee       575,023
Non-cash interest expense       34,020
Other-than temporary impairment (gain on recovery) of short-term and long-term investments     (4,390,487)  
Gain on disposition of fixed assets       (2,208)
Fair value of warrants for finder's fee       433,750
Changes in operating assets and liabilities:        
Prepaid contract research and manufacturing expenses, other prepaid expenses and other assets (404,377) (139,164) 303,665 (967,114)
Accounts payable, accrued contract research and manufacturing expenses and other accrued expenses (200,603) 2,882,709 (2,588,850) 11,818,460
Accrued compensation and related expenses 252,355 272,386 314,821 1,419,437
Net cash used in operating activities (48,039,584) (32,251,773) (30,390,169) (160,601,498)
Investing activities:        
Acquisitions of property and equipment (227,468) (151,836) (14,037) (714,473)
Proceeds from sale of assets       3,677
Purchases of short-term investments (65,605,570)     (115,143,906)
Redemptions of short-term investments 61,105,570 11,450,000 14,575,000 110,643,906
Security deposits (172) 38,855   (38,267)
Net cash (used in) provided by investing activities (4,727,640) 11,337,019 14,560,963 (5,249,063)
Financing activities:        
Proceeds from borrowings from affiliate       1,745,000
(Repayment of) borrowings from line of credit   (11,466,012) 4,188,544  
Proceeds from exercise of stock options       80,729
Proceeds from exercise of common stock warrants 8,480,135 275,331   9,054,546
Proceeds from sales of equity securities, net of issuance costs 37,726,538 57,403,841 12,402,758 196,398,165
Receipt of recovery of short-swing profits 73,797     73,797
Recapitalization of the Company       (400,000)
Receipt of cash for stock subscription receivable       4,625
Net cash provided by financing activities 46,280,470 46,213,160 16,591,302 206,956,862
Net (decrease) increase in cash and cash equivalents (6,486,754) 25,298,406 762,096 41,106,301
Cash and cash equivalents, beginning of period 47,593,055 22,294,649 21,532,553  
Cash and cash equivalents, end of period 41,106,301 47,593,055 22,294,649 41,106,301
Supplemental disclosure of cash flow information:        
Cash paid for interest   $ 70,389 $ 149,019 $ 224,328