X0303 4 2010-11-04 0 0001333763 Chelsea Therapeutics International, Ltd. CHTP 0001316746 Riehle J Nick 3530 TORINGDON WAY SUITE 200 CHARLOTTE NC 28277 0 1 0 0 Chief Financial Officer Common Stock 2010-11-04 4 P 0 3000 4.83 A 66183 D Stock Option (Right to Buy) 2.96 2020-01-19 Common Stock 50000 50000 D Stock Option (Right to Buy) 1.78 2019-01-22 Common Stock 50000 50000 D Stock Option (Right to Buy) 6.50 2018-01-24 Common Stock 50000 50000 D Stock Option (Right to Buy) 5.68 2017-02-06 Common Stock 50000 50000 D Stock Option (Right to Buy) 3.26 2016-01-19 Common Stock 50000 50000 D Stock Option (Right to Buy) 2.62 2015-01-10 Common Stock 68923 68923 D Option vests in four equal annual installments beginning on January 19, 2011. Option vests in four equal annual installments beginning on January 22, 2010. Option vests in four equal annual installments beginning on January 24, 2009. Option vests in four equal annual installments beginning on February 6, 2008. Option vests in four equal annual installments beginning on January 19, 2007. Option vested in four equal annual installments beginning on January 10, 2006. /s/ J. Nick Riehle 2010-11-04