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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
9 Months Ended 126 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Operating activities:      
Net loss $ (29,507,800) $ (37,993,831) $ (212,833,301)
Adjustments to reconcile net loss to net cash used in operating activities:      
Non-cash stock-based compensation 1,385,400 2,015,150 10,376,056
Depreciation and amortization 97,441 87,780 519,421
Stock issued for license agreement 0 0 575,023
Non-cash interest expense 0 0 34,020
Loss on disposition of assets 37,388 0 35,181
Fair value of warrants for finder's agreement 0 0 433,750
Changes in operating assets and liabilities:      
Prepaid contract research and manufacturing expenses, other prepaid expenses and other assets 379,203 (551,213) (587,911)
Accounts payable, accrued contract research and manufacturing expenses and other accrued expenses (6,942,266) 442,197 4,876,191
Accrued compensation and related expenses (1,209,676) 15,697 209,761
Accrued restructuring 1,026,931 0 1,026,931
Net cash used in operating activities (34,733,379) (35,984,220) (195,334,878)
Investing activities:      
Acquisitions of property and equipment (25,260) (174,286) (739,732)
Proceeds from sale of assets 0 0 3,677
Purchases of short-term investments 0 (65,608,361) (115,143,906)
Redemptions and sales of short-term investments 4,500,000 45,105,570 115,143,906
Security deposits 38,267 0 0
Net cash provided by (used in) investing activities 4,513,007 (20,677,077) (736,055)
Financing activities:      
Proceeds from borrowings from affiliate 0 0 1,745,000
Proceeds from exercise of stock options 0 0 80,729
Proceeds from exercise of common stock warrants 0 8,372,465 9,054,546
Recapitalization of the Company 0 0 (400,000)
Proceeds from sales of equity securities, net of issuance costs 22,151,851 37,726,538 218,550,016
Receipt of recovery of short-swing profits 0 73,103 73,797
Receipt of cash for stock subscription receivable 0 0 4,625
Net cash provided by financing activities 22,151,851 46,172,106 229,108,713
Net (decrease) increase in cash and cash equivalents (8,068,521) (10,489,191) 33,037,780
Cash and cash equivalents, beginning of period 41,106,301 47,593,055 0
Cash and cash equivalents, end of period 33,037,780 37,103,864 33,037,780
Supplemental disclosure of cash flow information:      
Cash paid for interest $ 0 $ 0 $ 224,328