X0306 4 2019-09-09 0 0001131324 GENOMIC HEALTH INC GHDX 0001333482 Popovits Kimberly J 301 PENOBSCOT DR. REDWOOD CITY CA 94063 1 1 0 0 President and CEO Common Stock 2019-08-22 5 G 0 E 10200 0.00 D 88268 I Held by the Popovits 2010 Trust Common Stock 2019-09-09 4 S 0 6917 72.0978 D 81351 I Held by the Popovits 2010 Trust Common Stock 2019-09-09 4 S 0 2483 73.3488 D 78868 I Held by the Popovits 2010 Trust Common Stock 2019-09-09 4 S 0 600 74.0992 D 78268 I Held by the Popovits 2010 Trust Common Stock 36168 D Common Stock 12298 I Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits These sales of common stock were effected pursuant to Rule 10b5-1 sales plan adopted by the reporting person on December 10, 2018. Reporting person undertakes to provide upon request by the Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within the range indicated. Represents weighted average sale price. Actual sale prices ranged from $71.69 to $72.67. Represents weighted average sale price. Actual sale prices ranged from $72.69 to $73.68. Represents weighted average sale price. Actual sale prices ranged from $73.73 to $74.46. Represents shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. /s/ Jason W. Radford, Attorney-in-fact 2019-09-11