X0306 4 2019-08-12 0 0001131324 GENOMIC HEALTH INC GHDX 0001333482 Popovits Kimberly J 301 PENOBSCOT DR. REDWOOD CITY CA 94063 1 1 0 0 President and CEO Common Stock 2019-08-12 4 M 0 25000 29.34 A 133468 I Held by the Popovits 2010 Trust Common Stock 2019-08-12 4 S 0 24553 73.2979 D 108915 I Held by the Popovits 2010 Trust Common Stock 2019-08-12 4 S 0 447 73.7588 D 108468 I Held by the Popovits 2010 Trust Common Stock 2019-08-13 4 M 0 15000 29.34 A 123468 I Held by the Popovits 2010 Trust Common Stock 2019-08-13 4 S 0 7393 73.724 D 116075 I Held by the Popovits 2010 Trust Common Stock 2019-08-13 4 S 0 7607 74.6802 D 108468 I Held by the Popovits 2010 Trust Common Stock 2019-08-13 4 S 0 4909 73.7224 D 103559 I Held by the Popovits 2010 Trust Common Stock 2019-08-13 4 S 0 5091 74.6734 D 98468 I Held by the Popovits 2010 Trust Common Stock 12298 I Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits Common Stock 36168 D Employee Stock Option (right to buy) 29.34 2019-08-12 4 M 0 25000 0.00 D 2022-02-03 Common Stock 25000 15000 D Employee Stock Option (right to buy) 29.34 2019-08-13 4 M 0 15000 0.00 D 2022-02-03 Common Stock 15000 0 D These sales of common stock were effected pursuant to Rule 10b5-1 sales plan adopted by the reporting person on December 10, 2018. Reporting person undertakes to provide upon request by the Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within the range indicated. Represents weighted average sale price. Actual sale prices ranged from $72.73 to $73.70. Represents weighted average sale price. Actual sale prices ranged from $73.74 to $73.78. Represents weighted average sale price. Actual sale prices ranged from $73.08 to $74.05. Represents weighted average sale price. Actual sale prices ranged from $74.11 to $75.10. Represents weighted average sale price. Actual sale prices ranged from $73.08 to $74.02. Represents shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. The option became exercisable as to 25% of the shares on February 3, 2013, and became exercisable as to 1/48th of the shares each full month thereafter. /s/ Jason W. Radford, Attorney-in-fact 2019-08-14