X0306 4 2018-10-15 0 0001131324 GENOMIC HEALTH INC GHDX 0001333482 Popovits Kimberly J 301 PENOBSCOT DR. REDWOOD CITY CA 94063 1 1 0 0 President and CEO Common Stock 2018-10-15 4 M 0 25000 22.98 A 201982 I Held by the Popovits 2010 Trust Common Stock 2018-10-15 4 S 0 23720 64.2632 D 178262 I Held by the Popovits 2010 Trust Common Stock 2018-10-15 4 S 0 880 64.7886 D 177382 I Held by the Popovits 2010 Trust Common Stock 2018-10-15 4 S 0 400 65.76 D 176982 I Held by the Popovits 2010 Trust Common Stock 2018-10-16 4 M 0 25000 22.98 A 201982 I Held by the Popovits 2010 Trust Common Stock 2018-10-16 4 S 0 2795 64.4461 D 199187 I Held by the Popovits 2010 Trust Common Stock 2018-10-16 4 S 0 6103 65.4139 D 193084 I Held by the Popovits 2010 Trust Common Stock 2018-10-16 4 S 0 8217 66.4277 D 184867 I Held by the Popovits 2010 Trust Common Stock 2018-10-16 4 S 0 7885 67.3862 D 176982 I Held by the Popovits 2010 Trust Common Stock 59517 D Common Stock 12298 I Held by Morgan Stanley as Custodian for Benefit of Kimberly Popovits Employee Stock Option (right to buy) 22.98 2018-10-15 4 M 0 25000 0.00 D 2021-01-27 Common Stock 25000 65000 D Employee Stock Option (right to buy) 22.98 2018-10-16 4 M 0 25000 0.00 D 2021-01-27 Common Stock 25000 40000 D These sales of common stock were effected pursuant to Rule 10b5-1 sales plan adopted by the reporting person on August 14, 2018. Reporting person undertakes to provide upon request by the Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within the range indicated. Represents weighted average sale price. Actual sale prices ranged from $63.64 to $64.63. Represents weighted average sale price. Actual sale prices ranged from $64.64 to $65.55. Represents actual sale price. Represents weighted average sale price. Actual sale prices ranged from $63.97 to $64.96. Represents weighted average sale price. Actual sale prices ranged from $64.97 to $65.96. Represents weighted average sale price. Actual sale prices ranged from $65.97 to $66.96. Represents weighted average sale price. Actual sale prices ranged from $66.97 to $67.73. Includes an aggregate of 51,204 shares of common stock issuable pursuant to previously reported restricted stock units that have not vested. The option became exercisable as to 25% of the shares on January 27, 2012, and became exercisable as to 1/48th of the shares each full month thereafter. Note: The shares previously reported as held in trust for the benefit of Ms. Popovits' son, of which Ms. Popovits was trustee, are held directly by her son and are not an indirect holding of Ms. Popovits. /s/ Jason W. Radford, Attorney-in-fact 2018-10-17