X0303 4 2010-11-15 0 0001131324 GENOMIC HEALTH INC GHDX 0001333482 Popovits Kimberly J 301 PENOBSCOT DRIVE REDWOOD CITY CA 94403 1 1 0 0 President and CEO Common Stock 2010-11-15 4 M 0 4000 2.88 A 292116 D Common Stock 2010-11-15 4 S 0 4000 17.6031 D 288116 D Common Stock 2010-11-16 4 M 0 4000 2.88 A 292116 D Common Stock 2010-11-16 4 S 0 4000 17.394 D 288116 D Common Stock 12298 I Held by UBS for Benefit of Kimberly Popovits Common Stock 10210 I Held by son Employee Stock Option (right to buy) 2.88 2010-11-15 4 M 0 4000 0.00 D 2014-12-02 Common Stock 4000 41614 D Employee Stock Option (right to buy) 2.88 2010-11-16 4 M 0 4000 0.00 D 2014-12-02 Common Stock 4000 37614 D The number of shares originally covered by the exercised option was 66,666 options an exercise price per share of $3.00 per share. In connection with the issuer's initial public offering on October 4, 2005, a conditional dividend was issued which increased the number of shares covered by the option by 2,062 to 69,348, reducing the effective exercise price per share to $2.88. This sale of common stock was effected persuant to a Rule 10b5-1 sales plan adopted by the reporting person on February 10, 2010. Reporting person undertakes to provide upon request by the Securities and Exchange Commission, the issuer or a securityholder of the issuer detailed information regarding the price and number of shares sold within the range indicated. Represents weighted average sale price. Actual sale prices ranged from $17.48 to $17.65. Represents weighted average sale price. Actual sale prices ranged from $17.2101 to $17.45. The option becomes exercisable as to 25% of the shares on December 2, 2004, and becomes exercisable as to 1/48th of the shares each full month thereafter. Kimberly J. Popovits 2010-11-17