X0303 4 2011-03-16 0 0001333248 CADENCE PHARMACEUTICALS INC CADX 0001466916 Byrd Scott A. C/O CADENCE PHARMACEUTICALS, INC. 12481 HIGH BLUFF DRIVE, STE 200 SAN DIEGO CA 92130 0 1 0 0 SVP, Chief Commercial Officer Stock option (right to buy) 8.55 2011-03-16 4 A 0 80000 A 2021-03-16 common stock 80000 80000 D 25% of the number of shares of common stock subject to the option vest one year after the date of grant, and 1/48th of the original number of shares of common stock subject to the option vest on the first day of each full month thereafter for so long as the option holder continues to provide services to the Corporation. Not applicable to this transaction. /s/ Hazel M. Aker Attorney-in-fact 2011-03-18