X0303 4 2009-02-18 0001333248 CADENCE PHARMACEUTICALS INC CADX 0001024000 BLAIR JAMES C C/O DOMAIN ASSOCIATES, LLC ONE PALMER SQUARE PRINCETON NJ 08542 1 0 1 0 Common Stock 2009-02-18 4 P 0 2734040 7.13 A 2734040 I By Domain Partners VII, L.P. Common Stock 2009-02-18 4 P 0 46634 7.13 A 46634 I By DP VII Associates, L.P. Warrants to Purchase Common Stock 7.84 2009-02-18 4 P 0 1367020 .125 A 2009-02-18 2014-02-18 Common Stock 1367020 1367020 I By Domain Partners VII, L.P. Warrants to Purchase Common Stock 7.84 2009-02-18 4 P 0 23317 .125 A 2009-02-18 2014-02-18 Common Stock 23317 23317 I By DP VII Associates, L.P. The Reporting Person is a Managing Member of One Palmer Square Associates VII, L.P., which is the sole general partner of Domain Partners VII, L.P. and DP VII Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. The Reporting Person also indirectly beneficially owns (i) 27,500 shares held by Domain Associates, LLC; (ii) 8,432,241 shares held by Domain Partners VI, L.P.; and (iii) 90,369 shares held by DP VI Associates, L.P. The Reporting Person is a Managing Member of Domain Associates, LLC and a Managing Member of One Palmer Square Associates VI, LLC, which is the sole general partner of Domain Partners VI, L.P. and DP VI Associates, L.P. Pursuant to Instruction 4(b)(iv) of Form 4, the Reporting Person has elected to report as indirectly beneficially owned the entire number of securities beneficially owned by each such entity. The Reporting Person disclaims beneficial ownership of any securities, and any proceeds thereof, that exceed his or her pecuniary interest therein and/or that are not actually distributed to him or her. /s/Kathleen K. Schoemaker, Attorney-in-Fact 2009-02-20